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Agents found to either delay the onset of Alzheimer’s (AD) or slow down its course
Zimbabwe Alzheimer’s and Related Disorders Association (ZARDA)
Extracted from March 2004 Newsletter
March 28, 2004

Published by Dr. Felix Potocnik, Dr. Susan van Rensburg and Dr. Christianne Bouwens – Dept. of Psychiatry, Chemical Pathology & Internal Medicine, University of Stellenbosch, South Africa.

1. Apolipoprotein E2 or 3;
2. hormone replacement therapy (initiated perimenopausally where indicated);
3. anti-inflammatories (low dose – preventative dose not yet established);
4. vitamin E (1000iu daily – preventative dose not yet established);
5. red wine (approximately 250 – 500 ml per day because of ingredients such as resveratrol);
6. intellectual stimulation and higher education (improves the number of synapses) and
7. most important is the control of cardiovascular risk factors such as: hypertension – taking into account raised age-acceptable blood pressures, diabetes mellitus – noting that in asymptomatic diabetics random blood-glucose levels up to 15 mmol/l are acceptable, prevention of platelet aggregation with – disprin 80 – 150 mg per day, hyperlipidaemia – via diet and medication i.e. serum lipid-lowering agents such as the HMG-CoA reductase inhibitors (e.g. statins), smoking – should be stopped, alchol – reducing consumption to an equivalent maximum of three tots of spirits per day, body mass index – dietary modification and regular exercise, endothelial stress and inflammation – thiamine supplementation, and hyperhomosysteinaemia – folic acid and vitamins B 6 and B 12 supplementation.

Visit the ZARDA fact sheet

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